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Article

Identification of a Risk Allele at SLC41A3 and a Protective Allele HLA-DPB1*02:01 Associated with Sarcopenia in Japanese.

Gerontology - 1 Jan 2025

Furutani Motoki, Kimura Tetsuaki, Fukunaga Koya, Suganuma Mutsumi, Takemura Marie, Matsui Yasumoto, Satake Shosuke, Nakano Yukiko, Mushiroda Taisei, Niida Shumpei, Ozaki Kouichi, Hosoyama Tohru, Shigemizu Daichi

Abstract excerpt

INTRODUCTION: Age-related alterations in muscle tissue morphology and function, as well as chronic pro-inflammatory conditions, contribute to the development of sarcopenia. To elucidate the multidimensional pathogenesis of sarcopenia, we performed a comprehensive genetic analysis, including common variants, rare variants, and human leukemia antigen (HLA). METHODS: A total of 129 older adults were analyzed using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40552851
DOI: 10.1159/000545298

Genes

SLC41A3
MYOG
MAF
ALDH2
CCHCR1
MYMK
SYNRG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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