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Safety and efficacy of live attenuated PEDV vaccines for neonatal protection

23 Jun 2025

Abstract excerpt

Porcine epidemic diarrhea virus (PEDV) causes severe diarrheal disease with high mortality in neonatal piglets. To protect suckling piglets, maternal vaccination strategies that induce lactogenic immunity in sows are crucial. To develop modified live vaccine candidates, we generated recombinant viruses with genome alterations such as deletion of the ORF3 accessory gene (ΔORF3), deletion of the N-terminal sialic...

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PMID: 40550792
DOI: 10.1038/s41541-025-01195-w

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