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Article

Diversity and evolutionary history of RNA viruses among different horseshoe crab species.

Journal of virology - 22 Jul 2025

Qi Yu-Hua, Ye Zhuang-Xin, Feng Ke-Hui, Ma Xiao-Wan, Zhang Chuan-Xi, Hu Meng-Hong, Shi Mang, Chen Jian-Ping, Li Jun-Min

Abstract excerpt

Horseshoe crabs (Xiphosura: Limulidae) are the sole surviving species of the class Merostomata, with only four extant species remaining today. Recent advances in metagenomic next-generation sequencing have unveiled a vast diversity of RNA viruses and non-retroviral endogenous RNA viral elements (nrEVEs) in invertebrates. This raises intriguing questions about the RNA virome and nrEVEs in horseshoe crabs as...

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Identifiers

PMID: 40539782
DOI: 10.1128/jvi.00164-25
PMCID: PMC12282059

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