Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Homozygous familial hypercholesterolemia in a high-consanguinity population: Insights from a Saudi cohort.

Journal of clinical lipidology - 1 Jan 2025

Alsagheir Afaf, Abdullah Ismail A, Albitar Mohammed, Aljaser Alhanouf, Alansari Rahaf, Ali Anas, Aldamouni Maeen, Alhosainy Ziad, Mohamed Rojina, Jaamour Heba, Alhuthil Raghad, Al-Hamoudi Saad, Aldayel Abdualziz, Aljumaa Mohammad, Khamaj Yara, Mcrabi Ali, Alquayt Meshari, Al-Ashwal Abdullah

Abstract excerpt

BACKGROUND: Homozygous familial hypercholesterolemia (HoFH) is a genetic disorder characterized by markedly elevated low-density lipoprotein cholesterol (LDL-C) levels and a significantly increased risk of early-onset cardiovascular disease (CVD) and premature death. This study investigates the clinical features, treatment outcomes, genetic findings, and reverse cascade screening results for HoFH patients....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholesterol, LDL
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Consanguinity

Share to Homozygote

Share to Hyperlipoproteinemia Type II

Share to Receptors, LDL

Share to Saudi Arabia

Share to Young Adult

Source

Identifiers

PMID: 40537310
DOI: 10.1016/j.jacl.2025.04.185

Genes

LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Homozygous familial hypercholesterolemia in a high-consanguinity population: Insights from a Saudi cohort.PMID 40537310Read ↗

Homozygous familial hypercholesterolemia (HoFH) in Canada.Semantic proximity Read ↗

Homozygous familial hypercholesterolemia in China: Genetic and clinical characteristics from a real-world, multi-center, cohort study.Semantic proximity Read ↗

Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society.Semantic proximity Read ↗

Clinical characteristics and lipid management of patients with familial hypercholesterolemia: results from a 7 years single-centre experience.Semantic proximity Read ↗

Familial Hypercholesterolemia: From Clinical Suspicion to Novel TreatmentsSemantic proximity Read ↗

Homozygous Familial Hypercholesterolemia in Spain: Prevalence and Phenotype-Genotype Relationship.Semantic proximity Read ↗

A nationwide genetic and phenotypic spectrum of 63 probands of homozygous familial hypercholesterolemia in Taiwan.Semantic proximity Read ↗

Clinical and molecular characteristics of homozygous familial hypercholesterolemia patients: Insights from SAFEHEART registry.Semantic proximity Read ↗

Familial Hypercholesterolemia: A Narrative Review on Diagnosis and Management Strategies for Children and Adolescents.Semantic proximity Read ↗

Familial Hypercholesterolemia: Prevalence and Discrepancy between Genotype and Phenotype. Findings of the Population-based Hamburg City Health Study.Semantic proximity Read ↗

The Prevalence and Genetic Spectrum of Familial Hypercholesterolemia in Qatar Based on Whole Genome Sequencing of 14,000 SubjectsSemantic proximity Read ↗

Identification of Novel and Known LDLR Variants Triggering Severe Familial Hypercholesterolemia in Saudi Families.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.