Rapamycin, Not Metformin, Mirrors Dietary Restriction‐Driven Lifespan Extension in Vertebrates: A Meta‐Analysis

Abstract excerpt

Dietary restriction (DR) robustly increases lifespan across taxa. However, in humans, long-term DR is difficult to maintain, leading to the search for compounds that regulate metabolism and increase lifespan without reducing caloric intake. The magnitude of lifespan extension from two such compounds, rapamycin and metformin, remains inconclusive, particularly in vertebrates. Here, we conducted a meta-analysis...

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