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Article

Revisiting Abnormalities of Ventricular Depolarization: Redefining Phenotypes and Associated Outcomes Using Tree-Based Dimensionality Reduction.

Journal of the American Heart Association - 1 Jul 2025

Gurnani Mehak, Patlatzoglou Konstantinos, Barker Joseph, Bivona Derek, Pastika Libor, Sieliwonczyk Ewa, Zeidaabadi Boroumand, Inglese Paolo, Curran Lara, Arnold Ahran D, O'Regan Declan, Whinnett Zachary, Bilchick Kenneth C, Peters Nicholas S, Kramer Daniel B, Waks Jonathan W, Sau Arunashis, Ng Fu Siong

Abstract excerpt

BACKGROUND: Abnormal ventricular depolarization, evident as a broad QRS complex on an ECG, is traditionally categorized into left bundle-branch block (LBBB) and right bundle-branch block or nonspecific intraventricular conduction delay. This categorization, although physiologically accurate, may fail to capture the nuances of diseases subtypes. METHODS: We used unsupervised machine learning to identify and...

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Identifiers

PMID: 40530476
DOI: 10.1161/JAHA.124.040814
PMCID: PMC12449969

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