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Exploring potential targets and mechanisms of PCB52-induced cardiotoxicity: Integration of network toxicology and zebrafish experimental evidence

16 Jun 2025

Abstract excerpt

2,2',5,5'-Tetrachlorobiphenyl (PCB52) exhibits high environmental mobility and bioaccumulation potential. Studies have associated elevated levels of serum PCB52 with an increased risk of cardiac diseases, yet the underlying mechanisms of its cardiotoxicity remain inadequately investigated. In this study, potential PCB52 targets and cardiotoxicity-related targets were retrieved from multiple online databases, and...

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PMID: 40527023
DOI: 10.1016/j.ecoenv.2025.118531

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