Article
Universal versus targeted chlorhexidine and mupirocin decolonisation and clinical and molecular epidemiology of Staphylococcus epidermidis bloodstream infections in patients in intensive care in Scotland, UK: a controlled time-series and longitudinal genotypic study.
The Lancet. Microbe - 1 Aug 2025
Sharaf Sara, Lawes Timothy, Roos Deon, Okoliegbe Ijeoma, Alapati Susanth, Ribeiro Antonio, Nkene Istifanus, Ghezzi Daniele, Reid Stuart J, Austin Victoria, Ayansina Dolapo, Wilson Becky, Rehman Tanzeel, Parcell Benjamin J, Mellor Ian, Marwick Charis A, Oggioni Marco, Hijazi Karolin
Abstract excerpt
BACKGROUND: There are concerns that biocide skin and mucous membrane decolonisation, which is widely used to prevent health-care-associated infections in intensive care units (ICUs), might select for multidrug-resistant pathogens. We aimed to evaluate the effects of de-escalating from universal to targeted skin and nasal decolonisation on Staphylococcus epidermidis bloodstream infections (SE-BSI). METHODS: We did...
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