Association of xenobiotic-metabolizing gene cytochrome P450 2E1 variants with preeclampsia in Chinese women.

doi:10.1007/s43032-025-01890-y

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Association of xenobiotic-metabolizing gene cytochrome P450 2E1 variants with preeclampsia in Chinese women.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Oct 2025

Hu Kaifeng, Liu Qingqing, Liu Xinghui, Bai Huai, Wu Yujie, Fan Ping

Abstract excerpt

Environmental and genetic factors are related to the pathogenesis of preeclampsia (PE). Cytochrome P450 2E1 (CYP2E1) is crucial for the metabolism of endogenous and xenobiotic substances, possibly involved in the pathophysiology of PE. This study explored the association between CYP2E1 96-bp insertion/deletion (I/D) and rs2031920 (C-1054T) genetic variants and the risk of PE in 335 patients with PE and 1301...

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PMID: 40500574
DOI: 10.1007/s43032-025-01890-y
PMCID: PMC12546388

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CYP2E1

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