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Article

Children with Post COVID-19 Multisystem Inflammatory Syndrome Display Unique Pathophysiological Metabolic Phenotypes.

Journal of proteome research - 4 Jul 2025

Lawler Nathan G, Yonker Lael M, Lodge Samantha, Nitschke Philipp, Leonard Maureen M, Gray Nicola, Whiley Luke, Masuda Reika, Holmes Elaine, Wist Julien, Fasano Alessio, Nicholson Jeremy K

Abstract excerpt

SARS-CoV-2 infections in children lead to symptoms from mild respiratory illness to severe postacute sequelae of COVID-19, including multisystem inflammatory syndrome in Children (MIS-C). We conducted a metabolic profiling of 147 children's serum samples, including acute COVID-19 patients, MIS-C patients, and healthy controls. Using nuclear magnetic resonance spectroscopy and liquid chromatography-mass...

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Identifiers

PMID: 40490306
DOI: 10.1021/acs.jproteome.5c00062
PMCID: PMC12235697

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