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Biogenesis of DNA-carrying extracellular vesicles by the dominant human gut methanogenic archaeon

3 Jun 2025

Abstract excerpt

Abstract Extracellular vesicles (EVs) play many important roles in cells from all domains of life. Here, we characterize EVs produced by Methanobrevibacter smithii , the dominant methanogenic archaeon in the human gut, which contains a peptidoglycan cell wall. We show that M. smithii EVs are enriched in histones and diverse DNA repair proteins. Consistently, the EVs carry DNA and are strongly enriched in...

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PMID: 40461479
DOI: 10.1038/s41467-025-60272-9

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