Rapid detection of rifampin resistance in Mycobacterium tuberculosis using nucleotide MALDI-TOF MS: a comparative study with phenotypic drug susceptibility testing and DNA sequencing

Abstract excerpt

ABSTRACT Rifampin (RIF) resistance in Mycobacterium tuberculosis ( M.tb ) is primarily caused by mutations in the rpoB gene. Rapid and accurate detection of RIF resistance is critical for effective tuberculosis (TB) control. Nucleotide matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is an emerging technology used to detect RIF resistance-associated rpoB mutations in 210...

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