Article
Rapid detection of rifampin resistance in Mycobacterium tuberculosis using nucleotide MALDI-TOF MS: a comparative study with phenotypic drug susceptibility testing and DNA sequencing.
Microbiology spectrum - 1 Jul 2025
Zhang Junxian, Zhang Haiyan, Wang Jie, Sun Wenna, Liang Yan, Yang Yourong, Ma Qingwei, Wu Xueqiong
Abstract excerpt
Rifampin (RIF) resistance in Mycobacterium tuberculosis (M.tb) is primarily caused by mutations in the rpoB gene. Rapid and accurate detection of RIF resistance is critical for effective tuberculosis (TB) control. Nucleotide matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is an emerging technology used to detect RIF resistance-associated rpoB mutations in 210 M.tb...
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