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Reliability of Matrix-Assisted Laser Desorption-Ionisation Time-of-Flight Mass Spectrometry as a Method for Drug-Resistant Tuberculosis Gene Identification.

Clinical and experimental pharmacology & physiology - 1 Jun 2025

Zhao Kaishun, Wei Wei, Yang Lijia, Chen Wei, Liang Haiying, Jin Ye, Sun Yameng, Xu Jun, Yu Yanfang

Abstract excerpt

Instances of drug-resistant tuberculosis (TB), particularly multidrug- and extensive drug-resistant TB, are escalating worldwide; therefore, there is an urgent need to explore suitable treatment strategies. This study assessed the precision of matrix-assisted laser desorption-ionisation time-of-flight mass spectrometry (MALDI-TOF MS) in detecting drug-resistant TB. We developed a multiplex MALDI-TOF MS detection...

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PMID: 40275556
DOI: 10.1111/1440-1681.70038

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