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Article

Evaluating the Use of iPSC-Derived Models in Understanding the Pathogenesis of Childhood Interstitial Lung Disease.

Pediatric pulmonology - 1 May 2025

Jinson Swetha, Shanthikumar Shivanthan, Werder Rhiannon B

Abstract excerpt

RATIONALE: Genetic testing has significantly improved the diagnosis of childhood interstitial lung diseases (chILD), which have long challenged clinicians due to their heterogeneity and poor characterization. It is now imperative to study variants of unknown significance (VUS) to identify pathogenic mutations to optimize diagnosis and screening in patients. Furthermore, the limited treatment options for patients...

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Topics

Humans
Induced Pluripotent Stem Cells
Lung Diseases, Interstitial
Child
Hermanski-Pudlak Syndrome
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 40432281
DOI: 10.1002/ppul.71143
PMCID: PMC12117302

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