Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In silico screening and identification of CTL and HTL epitopes in the secreted virulence factors of Mycobacterium tuberculosis

31 Mar 2025

Abstract excerpt

Background: Mycobacterium tuberculosis (MTb) is a highly infectious pathogen and a global health threat due to its resilient cell wall and immune evasion strategies. Despite the availability of the antituberculosis Bacille Calmette-Guérin (BCG) vaccine, its efficacy varies (0%–80%) and gradually decreases over time. This study aimed to identify cytotoxic T-lymphocyte (CTL) and helper T-lymphocyte (HTL) epitopes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune responses and vaccinations
Share to Tuberculosis Research and Epidemiology
Share to vaccines and immunoinformatics approaches

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40401127
DOI: 10.5114/bta/201461

Provenance

PubMed metadata and Literature Corpus relationships.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In silico screening and identification of CTL and HTL epitopes in the secreted virulence factors of Mycobacterium tuberculosisPMID 40401127Read ↗

Immunoinformatics and structural aided approach to develop multi-epitope based subunit vaccine against Mycobacterium tuberculosisSemantic proximity Read ↗

A vaccine for global eradication of TB - A novel conceptual framework and design of a potent peptide-based vaccine with universal coverage through advanced computational vaccinologySemantic proximity Read ↗

Epitope promiscuity and population coverage of Mycobacterium tuberculosis protein antigens in current subunit vaccines under development.Semantic proximity Read ↗

Novel In Silico mRNA vaccine design exploiting proteins of M. tuberculosis that modulates host immune responses by inducing epigenetic modificationsSemantic proximity Read ↗

Computational identification and characterization of antigenic properties of Rv3899c of <i>Mycobacterium tuberculosis</i> and its interaction with Human leukocyte antigen (HLA)Semantic proximity Read ↗

Whole genome identification of Mycobacterium tuberculosisvaccine candidates by comprehensive data mining and bioinformatic analysesSemantic proximity Read ↗

A Review on T Cell Epitopes Identified Using Prediction and Cell-Mediated Immune Models for Mycobacterium tuberculosis and Bordetella pertussisSemantic proximity Read ↗

In silico Analysis and Experimental Validation of <b><i>Mycobacterium tuberculosis</i></b>-Specific Proteins and Peptides of <b><i>Mycobacterium tuberculosis</i></b> for Immunological Diagnosis and Vaccine DevelopmentSemantic proximity Read ↗

An Immunoinformatic strategy to develop new Mycobacterium tuberculosis multi-epitope vaccineSemantic proximity Read ↗

Immunodominant Mycobacterium tuberculosis Protein Rv1507A Elicits Th1 Response and Modulates Host Macrophage Effector FunctionsSemantic proximity Read ↗

Secretome Prediction of Two M. tuberculosis Clinical Isolates Reveals Their High Antigenic Density and Potential Drug TargetsSemantic proximity Read ↗

In silico analysis for the development of multi-epitope vaccines against Mycobacterium tuberculosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.