Article
Genome diversity and signatures of natural selection in mainland Southeast Asia.
Nature - 1 Jul 2025
He Yaoxi, Zhang Xiaoming, Peng Min-Sheng, Li Yu-Chun, Liu Kai, Zhang Yu, Mao Leyan, Guo Yongbo, Ma Yujie, Zhou Bin, Zheng Wangshan, Yue Tian, Liao Yuwen, Liang Shen-Ao, Chen Lu, Zhang Weijie, Chen Xiaoning, Tang Bixia, Yang Xiaofei, Ye Kai, Gao Shenghan, Lu Yurun, Wang Yong, Wan Shijie, Hao Rushan, Wang Xuankai, Mao Yafei, Dai Shanshan, Gao Zongliang, Yang Li-Qin, Guo Jianxin, Li Jiangguo, Liu Chao, Wang Jianhua, Sovannary Tuot, Bunnath Long, Kampuansai Jatupol, Inta Angkhana, Srikummool Metawee, Kutanan Wibhu, Ho Huy Quang, Pham Khoa Dang, Singthong Sommay, Sochampa Somphad, Kyaing U Win, Pongamornkul Wittaya, Morlaeku Chutima, Rattanakrajangsri Kittisak, Kong Qing-Peng, Zhang Ya-Ping, Su Bing
Abstract excerpt
Mainland Southeast Asia (MSEA) has rich ethnic and cultural diversity with a population of nearly 300 million1,2. However, people from MSEA are underrepresented in the current human genomic databases. Here we present the SEA3K genome dataset (phase I), generated by deep short-read whole-genome sequencing of 3,023 individuals from 30 MSEA populations, and long-read whole-genome sequencing of 37 representative...
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