High-grade and Invasive Intraductal Papillary Mucinous Neoplasm of the Pancreas with STK11 Aberration Having Undergone Pancreatic Resection Three Times for Metachronous Intrapancreatic Recurrences: A Case Report and Review of the Literature.

doi:10.2169/internalmedicine.5076-24

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High-grade and Invasive Intraductal Papillary Mucinous Neoplasm of the Pancreas with STK11 Aberration Having Undergone Pancreatic Resection Three Times for Metachronous Intrapancreatic Recurrences: A Case Report and Review of the Literature.

Internal medicine (Tokyo, Japan) - 15 Nov 2025

Anan Hideyuki, Koshita Shinsuke, Kanno Yoshihide, Ogawa Takahisa, Kusunose Hiroaki, Sakai Toshitaka, Yonamine Keisuke, Miyamoto Kazuaki, Kozakai Fumisato, Okano Haruka, Hosokawa Kento, Oikawa Masaya, Tsuchiya Takashi, Noda Yutaka, Sawai Takashi, Itoh Taito, Omori Yuko, Furukawa Toru, Ito Kei

Abstract excerpt

A 56-year-old woman with high-grade or invasive intraductal papillary mucinous neoplasm (IPMN) underwent 3 pancreatic surgeries for initial and recurrent IPMN lesions. Immunostaining and genetic analyses of all lesions revealed a consistent mutation in KRAS and loss of serine/threonine kinase 11 (STK11), indicating the same origin of these lesions and the possibility of intraductal dissemination. Other...

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Identifiers

PMID: 40368785
DOI: 10.2169/internalmedicine.5076-24
PMCID: PMC12702538

Genes

STK11
KRAS

Provenance

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