Inhibition of PCSK9 with polypurine reverse hoogsteen hairpins: A novel gene therapy approach

Abstract excerpt

PCSK9 is a therapeutic target for hypercholesterolemia. Though different strategies to inhibit PCSK9, such as monoclonal antibodies, small molecules, or nucleic acid drugs are available, the need for safer and inexpensive interventions remains. We developed a time-, cost-, and resource- efficient silencing system using Polypurine Reverse Hoogsteen (PPRH) hairpins to target PCSK9 . To achieve PCSK9 silencing, we...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chronic Lymphocytic Leukemia Research
• Share to Computational Drug Discovery Methods
• Share to CRISPR and Genetic Engineering