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Article

CRISPR genome editing using a combined positive and negative selection system.

PloS one - 1 Jan 2025

Sharma Ishrya, Hall Kerisa, Moonah Shannon

Abstract excerpt

The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system is a powerful genome editing tool that has revolutionized research. Single nucleotide polymorphisms (SNPs) are the most common form of genetic variation in humans. Only a subset of these SNPs has been shown to be linked to genetic diseases, while the biological relevance of the majority remains unclear. Investigating these variants...

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PMID: 40327602
DOI: 10.1371/journal.pone.0321881
PMCID: PMC12054870

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