Article
Kompetitive allele specific PCR (KASP) based genotyping of sickle gene in the selected sub-ethnic tribal population of Gujarat and Madhya Pradesh.
Expert review of hematology - 1 Jun 2025
Budhbhatti Urvi, Prajapati Bhumika, Dave Bhagirath, Tripathi Aman, Joshi Chaitanya, Joshi Madhvi
Abstract excerpt
BACKGROUND: Indian tribal population is more vulnerable to sickle cell disease (SCD), an autosomal recessive disease caused by a single A>T transversion mutation in the HBB gene. Current study aims to develop a novel Kompetitive allele specific PCR (KASP) assay for genotyping of sickle gene in selected tribal communities of India. PATIENTS AND METHODS: The study was conducted from 2021 to 2023 involving 583...
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