Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inclusion of a retroviral protease enhances the immunogenicity of VLP-forming mRNA vaccines against HIV-1 or SARS-CoV-2 in mice

30 Apr 2025

Abstract excerpt

Messenger RNA (mRNA) has emerged as a highly effective and versatile platform for vaccine delivery. We previously designed a virus-like particle (VLP)–forming env-gag mRNA vaccine against human immunodeficiency virus–1 (HIV-1) that elicited envelope-specific neutralizing antibodies and protection from heterologous simian-human immunodeficiency virus (SHIV) infection in rhesus macaques. Here, we introduce a key...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatitis C virus research
Share to HIV Research and Treatment
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40305570
DOI: 10.1126/scitranslmed.adt9576

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inclusion of a retroviral protease enhances the immunogenicity of VLP-forming mRNA vaccines against HIV-1 or SARS-CoV-2 in micePMID 40305570Read ↗

Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primatesSemantic proximity Read ↗

The mRNA Vaccine Revolution: COVID-19 Has Launched the Future of VaccinologySemantic proximity Read ↗

mRNA vaccines for infectious diseases: principles, delivery and clinical translationSemantic proximity Read ↗

Platforms, advances, and technical challenges in virus-like particles-based vaccinesSemantic proximity Read ↗

Advancements of in vitro transcribed mRNA (IVT mRNA) to enable translation into the clinicsSemantic proximity Read ↗

RNA Vaccines: A Suitable Platform for Tackling Emerging Pandemics?Semantic proximity Read ↗

Enhancement of the HIV-1-Specific Immune Response Induced by an mRNA Vaccine through Boosting with a Poxvirus MVA Vector Expressing the Same AntigenSemantic proximity Read ↗

Trans-Amplifying RNA: A Journey from Alphavirus Research to Future VaccinesSemantic proximity Read ↗

Ability of nucleoside-modified mRNA to encode HIV-1 envelope trimer nanoparticlesSemantic proximity Read ↗

Characterization of a DNA vaccine expressing a human immunodeficiency virus-like particle.Semantic proximity Read ↗

Comparison of the immunogenicity of mRNA-encoded and protein HIV-1 Env–ferritin nanoparticle designsSemantic proximity Read ↗

mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.