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Zidesamtinib Selective Targeting of Diverse ROS1 Drug-Resistant Mutations

29 Apr 2025

Abstract excerpt

Zidesamtinib (NVL-520) is a ROS1-selective macrocyclic tyrosine kinase inhibitor designed with the aim to address clinical challenges for patients with non-small cell lung or other cancers that are ROS1 fusion-positive. These challenges include emergent ROS1 resistance mutations and brain metastases that can lead to disease progression and central nervous system adverse events attributed to off-target...

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PMID: 40299789
DOI: 10.1158/1535-7163.mct-25-0025

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