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Article

Progression of Atrophy as a Function of ABCA4 Variants and Age of Onset in Stargardt Disease.

Investigative ophthalmology & visual science - 1 Apr 2025

Pas Jeroen A A H, Li Catherina H Z, Van den Broeck Filip, Dhooge Patty P A, De Zaeytijd Julie, Collin Rob W J, Leroy Bart P, Hoyng Carel B

Abstract excerpt

Purpose: The purpose of this study was to assess the natural course of the retinal atrophy growth rate in patients with Stargardt disease (STGD1) with particular mutations in ABCA4, which may be eligible for mutation-specific therapy. Methods: Fundus autofluorescence images (Heidelberg Spectralis) were gathered from 221 patients (436 eyes) in two centers: Radboud UMC and Ghent University Hospital. The area of...

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Identifiers

PMID: 40293396
DOI: 10.1167/iovs.66.4.76
PMCID: PMC12060069

Genes

ABCA4

Variants

Provenance

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