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HJURP modulates cell proliferation and chemoresistance via the MYC/TOP2A transcriptional axis in gastric cancer

11 Apr 2025

Abstract excerpt

Background: The histone chaperone Holliday Junction Recognition Protein (HJURP) has been associated with multiple types of cancers, but its role in GC is not yet fully understood. Considering its functions in centromere stability and DNA repair, investigating HJURP's role in GC may offer novel therapeutic perspectives. Methods: HJURP expression was examined in a dataset comprising TCGA-STAD samples and an...

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PMID: 40290723
DOI: 10.3389/fmolb.2025.1566293

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