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Article

Illuminating the Noncoding Genome in Cancer Using Artificial Intelligence.

Cancer research - 2 Jul 2025

Alvarez-Torres Maria Del Mar, Fu Xi, Rabadan Raul

Abstract excerpt

Understanding the vast noncoding cancer genome requires cutting-edge, high-resolution, and accessible strategies. Artificial intelligence is revolutionizing cancer research, enabling advanced models to analyze genome regulation. This review examines illustrative examples of noncoding mutations in cancer, focusing on both key regulatory elements and risk-associated variants that remain poorly understood, and...

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Identifiers

PMID: 40261968
DOI: 10.1158/0008-5472.CAN-25-0482
PMCID: PMC12214880

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