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Vitamin D3 regulates sperm mitochondrial function essential for zebrafish reproductive ability: insights into non-classical roles

17 Apr 2025

Abstract excerpt

Vitamin D (VD) has attracted increasing research interest in recent years, mainly after several "non-classical" targets were identified, including the reproductive organs. Cytochrome P450 family member 27b1 (Cyp27b1) is the key enzyme for the conversion of VD3 to the active form 1,25(OH)2D3, which catalyzes the hydroxylation of 25(OH)D3 at the 1α position. Cyp27b1 is expressed in oocytes and testicular Sertoli...

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PMID: 40247687
DOI: 10.1093/biolre/ioaf092

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