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Article

Early Language Impairment as an Integral Part of the Cognitive Phenotype in Huntington's Disease.

Annals of clinical and translational neurology - 1 Jun 2025

Puig-Davi Arnau, Franch-Marti Carla, Ruiz-Barrio Iñigo, Sampedro Frederic, Perez-Perez Jesus, Matias-Guiu Jordi A, Cuetos Fernando, Olmedo-Saura Gonzalo, Perez-Carasol Laura, Horta-Barba Andrea, Aracil-Bolaños Ignacio, Pagonabarraga Javier, Kulisevsky Jaime, Martinez-Horta Saul

Abstract excerpt

OBJECTIVE: Huntington's disease (HD) speech/language disorders have typically been attributed to motor and executive impairment due to striatal dysfunction. In-depth study of linguistic skills and the role of extrastriatal structures in HD is scarce. This study aimed to explore the profile of language compromise in HD and identify the structural neuroimaging correlates. METHODS: Language and structural correlates...

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Identifiers

PMID: 40244831
DOI: 10.1002/acn3.70022
PMCID: PMC12172113

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