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Article

Protein Homeostasis Impairment Alters Phenotypic Heterogeneity of Biofilm Communities.

Molecular microbiology - 1 Jul 2025

Matavacas Judith, von Wachenfeldt Claes

Abstract excerpt

Biofilms are highly organized, cooperating communities of microorganisms encased in a self-produced extracellular matrix, providing resilience against external stress such as antimicrobial agents and host defenses. A hallmark of biofilms is their phenotypic heterogeneity, which enhances the overall growth and survival of the community. In this study, we demonstrate that removing the dnaK and tig genes encoding...

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Topics

Biofilms
Bacillus subtilis
Bacterial Proteins
HSP70 Heat-Shock Proteins
Homeostasis
Phenotype
Molecular Chaperones

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Proteostasis

Gene Expression Regulation, Bacterial

Polyglutamic Acid

Source

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Identifiers

PMID: 40243034
DOI: 10.1111/mmi.15366
PMCID: PMC12242103

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