The identification and prediction of lung adenocarcinoma prognosis using a novel gene signature associated with DNA replication

Abstract excerpt

Background: Lung adenocarcinoma (LUAD) is the most aggressive lung cancer phenotype, and patients’ clinical response is often limited by primary or acquired mechanisms of resistance to oncological therapy. One of the current clinical needs is to define clinical predictors for the prognosis of LUAD, aiming at offering patients a persistent treatment likely to delay disease progression as much as possible. This...

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