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From Wuhan to Omicron K.P2 strain: A comprehensive review of SARS-CoV-2 phylogeny and public health implications of the latest booster vaccine.

Human vaccines & immunotherapeutics - 1 Dec 2025

Akingbola Adewunmi, Adewole Olajumoke, Adegbesan Abiodun, Peters Favour, Odukoya Tolani, Aremu Olusola, Adeleke Oluwatimilehin, Idris Ayotomiwa, Owolabi Abdullahi, Aiyenuro Ademola

Abstract excerpt

The SARS-CoV-2 virus continues to evolve, with the Omicron KP.2 variant, a descendant of BA.2.86, emerging as a public health concern due to its rapid spread and resistance to existing immunity. This review examines the phylogenetic evolution of SARS-CoV-2, focusing on KP.2 and its key mutations (R346T, F456L, V1104L), alongside its epidemiological implications. It also discusses the development and approval of...

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Identifiers

PMID: 40214651
DOI: 10.1080/21645515.2025.2485840
PMCID: PMC12934171

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