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VCF2Dis: an ultra-fast and efficient tool to calculate pairwise genetic distance and construct population phylogeny from VCF files.

GigaScience - 6 Jan 2025

Xu Lian, He Weiming, Tai Shuaishuai, Huang Xiaoli, Qin Mumu, Liao Xun, Jing Yi, Yang Jian, Fang Xiaodong, Shi Jianhua, Jin Nana

Abstract excerpt

BACKGROUND: Genetic distance metrics are crucial for understanding the evolutionary relationships and population structure of organisms. Progress in next-generation sequencing technology has given rise of genotyping data of thousands of individuals. The standard Variant Call Format (VCF) is widely used to store genomic variation information, but calculating genetic distance and constructing population phylogeny...

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Identifiers

PMID: 40184433
DOI: 10.1093/gigascience/giaf032
PMCID: PMC11970368

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