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The potential of ARL4C and its-mediated genes in atherosclerosis and agent development

19 Mar 2025

Abstract excerpt

Foam cells are the risk factors for atherosclerosis. Recently, ARL4C, a member of the ADP-ribosylation factor family of GTP-binding proteins, was found to promote cholesterol efflux to decrease foam cell formation, suggesting that ARL4C may be a new promising target for the treatment of atherosclerosis. In fact, ARL4C regulated the expression of multiple atherosis-related genes, including ABCA1, ALDH1A3, ARF6,...

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PMID: 40176913
DOI: 10.3389/fphar.2025.1513340

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