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Article

RAB5 is a host dependency factor for the generation of SARS-CoV-2 replication organelles

1 Apr 2025

Abstract excerpt

ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a threat due to the emergence of variants with increased transmissibility and enhanced escape from immune responses. Like other coronaviruses before, SARS-CoV-2 likely emerged after its transmission from bats. The successful propagation of SARS-CoV-2 in humans might have been facilitated by usurping evolutionarily conserved cellular...

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PMID: 40167317
DOI: 10.1128/mbio.03314-24

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