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Article

Clinicopathological features of familial fibronectin glomerulopathy caused by a splice site variant in the Fibronectin 1 gene: a case report.

CEN case reports - 1 Jun 2025

Nagayama Yoshikuni, Otani Masako, Hashimoto Mariko, Ichikura-Iida Ayana, Inoue Takashi

Abstract excerpt

Fibronectin glomerulopathy (FNG) is a rare autosomal dominant inherited disease characterized by extensive deposits of fibronectin in the mesangium and subendothelial space of the glomeruli with membranoproliferative glomerulonephritis (MPGN)-like pattern. Currently, ten exonic and one intronic pathogenic variants in the fibronectin 1 gene have been identified; however, genotype-phenotype correlation data are...

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Topics

Humans
Female
Adult
Glomerulonephritis, Membranoproliferative
Nephrotic Syndrome
Fibronectins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

RNA Splice Sites

Glucocorticoids

Immunosuppressive Agents

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 40120032
DOI: 10.1007/s13730-025-00987-2
PMCID: PMC12126445

Provenance

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