Article
Rapidly progressive pediatric fibronectin glomerulopathy driven by a novel FN1 mutation (p.Thr1917del): implications for early diagnosis and recognition of systemic involvement.
Pediatric nephrology (Berlin, Germany) - 1 Oct 2026
Chen Xiaobin, Huang Jun, Chen Yi, Zhang Yunfan, Lin Jinfeng, Weng Zengfeng, Liu Jingjing, Xia Guizhi, Wang Chengfeng, Feng Ai, Tang Yuxian, Zhang Hannan, Nie Xiaojing
Abstract excerpt
BACKGROUND: This study characterizes a pediatric case of fibronectin glomerulopathy (FNG) caused by a novel FN1 variant and investigates the evidence for systemic involvement and genotype-phenotype correlations through a comprehensive literature review. METHODS: We report a female child diagnosed with FNG in February 2017 based on kidney biopsy and genetic testing at our institution. Clinical data and genetic...
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