Whole-genome sequencing characterisation of a new KPC-245 variant-carrying Klebsiella pneumoniae strain isolated from a transplanted patient and resistant to ceftazidime/avibactam, meropenem/vaborbactam and imipenem/relebactam

Abstract excerpt

• Klebsiella pneumoniae carbapenemase-carrying K. pneumoniae represents a significant threat to human health worldwide. • Whole-genome sequencing is a useful approach for understanding severe multidrug-resistant phenotypes. • A new bla KPC variant was identified that is potentially responsible for resistance to all new β-lactams/β-lactamase inhibitors tested as well as cefiderocol in a clinical isolate. In recent...

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