Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting the retinoid signaling pathway with YCT-529 for effective and reversible oral contraception in mice and primates

13 Mar 2025

Abstract excerpt

The retinoic acid receptor alpha (Rarα) has been validated as a male contraceptive target by genetic knockouts resulting in male sterility. The effects on spermatogenesis in the absence of RARα resemble the loss of RAR signaling in vitamin A deficiency, and the mice are otherwise normal. The effects on spermatogenesis in animals treated orally with the dual RARα/RARγ antagonist BMS-189453 closely phenocopies the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antioxidant Activity and Oxidative Stress
Share to Retinoids in leukemia and cellular processes
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40082579
DOI: 10.1038/s43856-025-00752-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting the retinoid signaling pathway with YCT-529 for effective and reversible oral contraception in mice and primatesPMID 40082579Read ↗

From concept to the clinic: Retinoic acid receptor α antagonist YCT‐529, an oral non‐hormonal male contraceptiveSemantic proximity Read ↗

The Role of Retinoic Acid in Spermatogenesis and Its Application in Male ReproductionSemantic proximity Read ↗

Schisandrin B for treatment of male infertilitySemantic proximity Read ↗

Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primatesSemantic proximity Read ↗

Inhibition of Retinoic Acid Biosynthesis by the Bisdichloroacetyldiamine WIN 18,446 Markedly Suppresses Spermatogenesis and Alters Retinoid Metabolism in MiceSemantic proximity Read ↗

Isotretinoin use is associated with persistent alterations in male reproductive functionSemantic proximity Read ↗

Scheduled simple production method of pseudopregnant female mice for embryo transfer using the luteinizing hormone-releasing hormone agonistSemantic proximity Read ↗

As the world grows: contraception in the 21st century.Semantic proximity Read ↗

Suppression of Spermatogenesis by Bisdichloroacetyldiamines Is Mediated by Inhibition of Testicular Retinoic Acid BiosynthesisSemantic proximity Read ↗

Retinoids and spermatogenesis: Lessons from mutant mice lacking the plasma retinol binding proteinSemantic proximity Read ↗

Male infertility caused by epididymal dysfunction in transgenic mice expressing a dominant negative mutation of retinoic acid receptor alpha 1.Semantic proximity Read ↗

Design and synthesis of androgen receptor antagonists with bulky side chains for overcoming antiandrogen resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.