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Article

Functional dissection of the C-terminal domain of rabies virus RNA polymerase L protein.

Journal of virology - 15 Apr 2025

Izumi Fumiki, Makino Machiko, Sasaki Michihito, Nakagawa Kento, Takahashi Tatsuki, Nishiyama Shoko, Fujii Yuji, Okajima Misuzu, Masatani Tatsunori, Igarashi Manabu, Sawa Hirofumi, Sugiyama Makoto, Ito Naoto

Abstract excerpt

The rabies virus large (L) protein interacts with its cofactor phosphoprotein (P protein) to function as an RNA-dependent RNA polymerase (RdRp). The C-terminal domain (CTD) of the L protein plays a critical role in P protein binding. We previously reported that the highly conserved NPYNE sequence in the hydrophilic region of the CTD (positions 1929-1933 of the L protein [L1929-1933]) is important for both P...

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Identifiers

PMID: 40066989
DOI: 10.1128/jvi.02082-24
PMCID: PMC11998541

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