Article
Molecular Function Analysis of Rabies Virus RNA Polymerase L Protein by Using an L Gene-Deficient Virus.
Journal of virology - 15 Oct 2017
Nakagawa Kento, Kobayashi Yuki, Ito Naoto, Suzuki Yoshiyuki, Okada Kazuma, Makino Machiko, Goto Hideo, Takahashi Tatsuki, Sugiyama Makoto
Abstract excerpt
While the RNA-dependent RNA polymerase L protein of rabies virus (RABV), a member of the genus Lyssavirus of the family Rhabdoviridae, has potential to be a therapeutic target for rabies, the molecular functions of this protein have remained largely unknown. In this study, to obtain a novel experimental tool for molecular function analysis of the RABV L protein, we established by using a reverse genetics approach...
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