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African swine fever virus vaccine strain Asfv-G-∆I177l reverts to virulence and negatively affects reproductive performance

6 Mar 2025

Abstract excerpt

ASFV-G-ΔI177L is a modified-live African swine fever virus (ASFV) strain that has been incorporated into a commercially available vaccine. Its safety in pregnant sows and genetic stability in an in vivo passaging experiment were investigated. Upon inoculation of two pregnant sows with ASFV-G-ΔI177L, one developed moderate ASF-related clinical signs. In terms of reproductive performance, 43% of the offspring was...

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PMID: 40050309
DOI: 10.1038/s41541-025-01099-9

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