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Deletion of the African swine fever virus E120R gene completely attenuates its virulence by enhancing host innate immunity and impairing virus release

3 Sept 2025

Abstract excerpt

African swine fever virus (ASFV) causes a lethal hemorrhagic disease in domestic pigs and represents a major threat to the global swine industry. Until now, no effective commercial vaccines or antiviral drugs are available for ASF control. In this study, we constructed a recombinant E120R gene-deleted virus, ASFV-ΔE120R, based on the highly virulent genotype II strain SY18, to investigate the biological role of...

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PMID: 40899401
DOI: 10.1080/22221751.2025.2555722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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