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Gut dysbiosis conveys psychological stress to activate LRP5/β-catenin pathway promoting cancer stemness

4 Mar 2025

Abstract excerpt

Psychological stress causes gut microbial dysbiosis and cancer progression, yet how gut microbiota determines psychological stress-induced tumor development remains unclear. Here we showed that psychological stress promotes breast tumor growth and cancer stemness, an outcome that depends on gut microbiota in germ-free and antibiotic-treated mice. Metagenomic and metabolomic analyses revealed that psychological...

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PMID: 40038255
DOI: 10.1038/s41392-025-02159-1

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