Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

KEAP1‐NRF2/HO‐1 Pathway Promotes Ferroptosis and Neuronal Injury in Schizophrenia

28 Feb 2025

Abstract excerpt

ABSTRACT Background This study investigates the role of the KEAP1‐NRF2/HO‐1 signaling pathway in inducing ferroptosis and contributing to neuronal damage in schizophrenia. Methods We retrieved schizophrenia‐related data and ferroptosis‐related genes from the RNA microarray dataset GSE27383 and FerrDB database, respectively. Bioinformatics data identified KEAP1 as a downregulated gene, which was validated using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ferroptosis and cancer prognosis
Share to Genomics, phytochemicals, and oxidative stress
Share to Tryptophan and brain disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40021790
DOI: 10.1002/brb3.70311

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KEAP1‐NRF2/HO‐1 Pathway Promotes Ferroptosis and Neuronal Injury in SchizophreniaPMID 40021790Read ↗

Identification of Ferroptosis-Related Genes in Schizophrenia Based on Bioinformatic AnalysisSemantic proximity Read ↗

Oxidative Stress-Related Mechanisms in Schizophrenia Pathogenesis and New Treatment Perspectives.Semantic proximity Read ↗

Hub genes, a diagnostic model, and immune infiltration based on ferroptosis-linked genes in schizophreniaSemantic proximity Read ↗

Revealing the Oxidative Stress-Related Molecular Characteristics and Potential Therapeutic Targets of Schizophrenia through Integrated Gene Expression Data AnalysisSemantic proximity Read ↗

Dysregulated Oxidative Stress Pathways in Schizophrenia: Integrating Single-Cell Transcriptomic and Human Biomarker EvidenceSemantic proximity Read ↗

NADPH-oxidase 4 gene over-expression in peripheral blood lymphocytes of the schizophrenia patientsSemantic proximity Read ↗

Hormesis, cellular stress response and neuroinflammation in schizophrenia: Early onset versus late onset stateSemantic proximity Read ↗

Cortical PGC-1α-Dependent Transcripts Are Reduced in Postmortem Tissue From Patients With SchizophreniaSemantic proximity Read ↗

A novel precision medicine framework based on the excitation-inhibition imbalance model, for treatment of schizophrenia across the life spanSemantic proximity Read ↗

The utility of SELENBP1 gene expression as a biomarker for major psychotic disorders: replication in schizophrenia and extension to bipolar disorder with psychosis.Semantic proximity Read ↗

Oxidative stress in schizophrenia: an integrated approach.Semantic proximity Read ↗

Polyunsaturated fatty acids (PUFA) Bimodality Unmasks xCT-Deficient Schizophrenia: Evidence of Two Distinct BiotypesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.