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Article

SFRP2 mediates Epstein-Barr virus and bladder cancer risk: a Mendelian randomization study and colocalization analysis.

Scientific reports - 28 Feb 2025

Li Jian, Yang Bing, Guo Lei, Huang Wenqi, Hu Qiong, Yan Hongting, Du Changpu, Tan Rong, Tang Dongxin

Abstract excerpt

Studies suggest a possible association between Epstein-Barr virus (EBV) infection and bladder cancer (BCa) risk, though this remains unclear. Secreted frizzled-related protein (sFRP) is also linked to BCa, with some DNA viruses potentially regulating its expression. This study used Mendelian randomization (MR) and colocalization analysis to explore the causal relationship between EBV infection, BCa risk, and the...

Read the complete abstract on PubMed

Topics

Humans
Mendelian Randomization Analysis
Epstein-Barr Virus Infections
Herpesvirus 4, Human
Urinary Bladder Neoplasms
Membrane Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Risk Factors

Genetic Predisposition to Disease

Polymorphism, Single Nucleotide

Secreted Frizzled-Related Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 40016549
DOI: 10.1038/s41598-025-91594-9
PMCID: PMC11868617

Genes

SFRP2

Provenance

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