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Acinetobacter baumannii OmpA hinders host autophagy via the CaMKK2-reliant AMPK-pathway

25 Feb 2025

Abstract excerpt

ABSTRACT Outer membrane protein A (OmpA) plays a vital role in the interactions between Acinetobacter baumannii and host cells. Autophagy is a defense mechanism that hinders the intracellular replication of bacteria, thereby safeguarding cells against microbial infections. While it has been observed that A. baumannii triggers cellular autophagy, the precise role of its virulence protein OmpA in this process...

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PMID: 39998213
DOI: 10.1128/mbio.03369-24

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