Comparing venetoclax in combination with hypomethylating agents to hypomethylating agent-based therapies for treatment naive TP53-mutated acute myeloid leukemia: results from the Consortium on Myeloid Malignancies and Neoplastic Diseases (COMMAND)

Abstract excerpt

TP53 is a tumor suppressor gene located on the short arm of chromosome 17(p13), known to be involved in multiple cellular processes and regulate cell proliferation by responding to various stress [ 1 , 2 ]. TP53 is a frequently mutated (m) gene found across diverse types of cancers, strongly linked to large structural and complex chromosomal abnormalities [ 3 , 4 ]. It is reported in 5–10% of patients diagnosed...

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