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Article

The impact of MTHFR and VDR polymorphisms on endometriosis susceptibility: Insights from a systematic review and meta-analysis.

Journal of reproductive immunology - 1 Mar 2025

Zhang Ruting, Lv Hanxin, Liu Jinghua, Yin Jiashan, Wu Shuang, Xie Yuyang, Xing Huihui, Wang Rui, Zhao Zefan, Shi Bimin, Yang Xiaoqin, Gao Shangshang

Abstract excerpt

The VDR and MTHFR polymorphisms have been linked to many gynecological and obstetrical diseases. However, there is still a pressing need for a systematic review and meta-analysis to synthesize the current evidence on the association between these variants and endometriosis risk. English and Chinese literature databases were systematically retrieved to find relevant research published up to August 1, 2024. The...

Read the complete abstract on PubMed

Topics

Humans
Methylenetetrahydrofolate Reductase (NADPH2)
Endometriosis
Female
Receptors, Calcitriol

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Polymorphism, Single Nucleotide

Alleles

Source

Identifiers

PMID: 39946760
DOI: 10.1016/j.jri.2025.104449

Genes

MTHFR
VDR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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