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Article

Proteomics profiling of inflammatory responses to elexacaftor/tezacaftor/ivacaftor in cystic fibrosis

28 Jan 2025

Abstract excerpt

Background CFTR modulator therapies have positive clinical outcomes, yet chronic inflammation and bacterial infections persist in people with CF (pwCF). How elexacaftor–tezacaftor–ivacaftor (ETI) fails to improve innate immune signaling responsible for bacterial clearance and inflammation resolution remains unknown. Methods We used an unbiased proteomics approach to measure the effect of ETI on inflammatory...

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PMID: 39935472
DOI: 10.3389/fimmu.2025.1486784

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