Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Establishment and characterization of ovarian clear cell carcinoma patient-derived xenografts.

Scientific reports - 5 Feb 2025

Caumanns Joseph J, Li Shang, Meersma Gert J, Duiker Evelien W, van der Zee Ate G J, Wisman G Bea A, de Jong Steven

Abstract excerpt

Interest in understanding the high chemoresistance and poor prognosis of advanced ovarian clear cell carcinoma (OCCC) is rising. Patient-derived xenografts (PDX) are widely used in vivo models because of their supposedly accurate morphologic and (epi)genetic representation of patient tumors. Here, we established five subcutaneous OCCC PDXs. The PDX.F1 engraftment success rate was over 30% with similar latency...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma, Clear Cell
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Copy Number Variations

Share to DNA Methylation

Share to Heterografts

Share to Ovarian Neoplasms

Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 39910133
DOI: 10.1038/s41598-025-86384-2
PMCID: PMC11799314

Genes

ARID1A
F2
ATM
BRCA1
PIK3CA
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Establishment and characterization of ovarian clear cell carcinoma patient-derived xenografts.PMID 39910133Read ↗

Establishment and molecular characterization of a human ovarian clear cell carcinoma cell line (FDOV1).Semantic proximity Read ↗

Characterization of Mutational Status, Spheroid Formation, and Drug Response of a New Genomically-Stable Human Ovarian Clear Cell Carcinoma Cell Line, 105C.Semantic proximity Read ↗

Translational genomics of ovarian clear cell carcinoma.Semantic proximity Read ↗

Establishment and its Utility of a Patient-Derived Cell Xenografts (PDCX) Model with Cryopreserved Cancer Cells from Human TumorSemantic proximity Read ↗

Creation and validation of a patient-derived cancer model using peritoneal and pleural effusion samples from patients with ovarian cancerSemantic proximity Read ↗

Molecular portraits of clear cell ovarian and endometrial carcinoma with comparison to clear cell renal cell carcinoma.Semantic proximity Read ↗

Ovarian clear cell adenocarcinoma: a continuing enigma.Semantic proximity Read ↗

Pathology of clear cell carcinoma of the ovary: A basic view based on cultured cells and modern view from comprehensive approaches.Semantic proximity Read ↗

Comprehensive molecular characterization identifies therapeutic vulnerabilities in ovarian clear cell carcinoma.Semantic proximity Read ↗

Review the progression of ovarian clear cell carcinoma from the perspective of genomics and epigenomicsSemantic proximity Read ↗

Patient Derived Xenografts for Genome-Driven Therapy of OsteosarcomaSemantic proximity Read ↗

Establishment and characterization of a cell line and patient-derived xenograft (PDX) from peritoneal metastasis of low-grade serous ovarian carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.