Detection and characterisation of high pathogenicity avian influenza virus (H5N1/H5N8) clade 2.3.4.4b, Hong Kong SAR, China, 2021 to 2024.

doi:10.2807/1560-7917.ES.2025.30.1.2400839

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Detection and characterisation of high pathogenicity avian influenza virus (H5N1/H5N8) clade 2.3.4.4b, Hong Kong SAR, China, 2021 to 2024.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin - 1 Jan 2025

Sun Wanying, Choy Ka Tim, Cheng Ka Man, Brackman Christopher J, Cheng Samuel Ms, Sit Thomas Hc, Tse Anne Cn, Sims Leslie D, Gu Haogao, Tang Amy Wy, Wong Andrew Nc, Tsang Andrew Tl, Koo Joe Ct, Luk Leo Lh, Yen Hui-Ling, Peris Malik, Poon Leo Lm

Abstract excerpt

We isolated three genotypes of highly pathogenic avian influenza virus (HPAIV) clade 2.3.4.4b from wild birds infected with H5N1 (n = 12) and H5N8 (n = 1) in Hong Kong SAR 2021-2024. Viruses from two spoonbills from late 2022 were genetically related to a virus from a human in China. Four tested viruses exhibited variable virulence in mice but were susceptible to approved antivirals. No neutralising antibody was...

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Topics

Animals
Influenza in Birds
Humans
Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Influenza A Virus, H5N1 Subtype

Hong Kong

Birds

Influenza A Virus, H5N8 Subtype

Influenza, Human

Genotype

Phylogeny

Virulence

Animals, Wild

China

Antibodies, Neutralizing

Antiviral Agents

Source

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Identifiers

PMID: 39790075
DOI: 10.2807/1560-7917.ES.2025.30.1.2400839
PMCID: PMC11719804

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